A project with such little detail that is often dismissed as modeler kit bash, the stug E-75 is possibly the most elusive E-series project discussed by Ernst Kniepkamp's team.
Although it was a logical extension of the supposedly "standard panzer" E-50/75 chassis, it wasn't until a very careful reading of Spielberger's "Special panzer variants" that I could find a reliable source.
Even there, it just briefly mentioned that the new layout design features gave an increase of 66% in interior space and brought the gross weight to 80 tons.
Further data is given on "Waffen und Geheimwaffen des deutschen heeres 1933-1945" by Fritz Hahn.
Although no design details are available, the planned armament is: 15cm L/52 with an heavy shell weighing around 42 kilos and the weight is pushed up to 85 tons.
This gives a very ambitious project with a hefty engineering challenge.
For comparison, the Jagdtiger had a 12.8cm L/55, a gun just above 7m at 704cm.
Below, Krupp's rejected proposal of arming Jagdtiger with a 12.8cm L/66:
At almost 8.5m long, the project was deemed unpractical as it would severely reduce maneuverability and likely gun traverse, changing it from a tank destroyer to armored artillery in Wa Pruef 6's words.
At 7.8m, a 150mm L/52 would be halfway between the two guns in length although likely close to the latter in weight.
Assuming a relatively low recoil cannon (at this stage of the war HEAT would have been the preferred piercing warhead rather than hypervelocity APCR, especially at such high caliber) firing at no more than 600-700 m/s it's likely casemate size requirements wouldn't change from what would have been needed to house the 12.8cm Pak 44 and given that size would be very similar to the Jagdtiger (even the marginally longer Weserhütte plans gave out just enough room to allow rear transmission), meaning anything larger would be highly unpractical.
Assuming minimal engineering and base chassis modification efforts would be allowed (this is the E-series we're talking about, so anything hampering ease of production would be likely avoided), this leaves us two possible possible configurations, one based on the aborted Jagdpanther mit 12.8 Pak 44 and the other being the classical Jagdtiger.
Using Doyle's designs from Panzer Tracts 20-1 we obtain mixed drawings that might look a bit closer to what german engineers had imagined:
The Jagdtiger-like casemate closer to the center would instead provide better balance as advantage and be closer to historical production reality as it would require relatively less production changes from the design already in the assembly lines.
All in all, given the war ended before even the early suspension tests on a Tiger II hull could be completed this represents mostly an exercise in speculation, although one extremely interesting for the historically minded war-game fan.